Special seminar of interest: Cryo-EM and 3D electron microscopy
Friday, December 1, 2017
11:00 a.m.
Marker​ ​Seminar room 0112​ of the Chemistry Building
For More Information:

Dr. Sriram Subramaniam
National Cancer Institute, NIH, Bethesda, MD.
http://electron.nci.nih.gov

Recent advances in “cryo-electron microscopy” (cryo-EM) technology and related methods have sparked a revolution in atomic resolution 3-D imaging that enable determination of structures of biological macromolecules in their native state. Knowledge of the three-dimensional shapes of genes, proteins, protein complexes, viruses, cells and tissue are essential not just to understanding biology but to the process of successful, cost-effective drug design and predicting disease outcomes. Cryo-EM technology is just the beginning of a much larger revolution in imaging biological complexity at the interface between engineering, physics, biology and medicine. In my talk, I will discuss recent work in my lab on developing some of these technologies, their application to important problems in infectious disease, cancer and neuroscience, as well as their potential to accelerate drug discovery and enable transformative approaches to personalized medicine.