December 3, 2021 UMD Home FabLab AIMLab

BioE graduate student and Bentley Group member Jessica Terrell in Trento, Italy.

BioE graduate student and Bentley Group member Jessica Terrell in Trento, Italy.


Fischell Department of Bioengineering (BioE) graduate student Jessica Terrell has departed for the Centre for Integrative Biology at the University of Trento, Italy, where she will spend two months working in Professor Sheref S. Mansy's research group.

Terrell, a member of BioE professor and Chair William E. Bentley's Biomolecular and Metabolic Engineering Laboratories, will build artificial cells composed of a lipid bilayer and the cellular machinery required to transcribe and translate genes into functional proteins. The synthetic cells are designed to interact with each other and with bacteria through quorum sensing, a form of intercellular communication based on the release and detection of signaling molecules. For the past several years, the Bentley Group has explored how manipulating this chemical language could prevent bacteria from engaging in pathogenic activity, or encourage them to take a positive action.

Prior to Terrell's visit, Mansy sent his advisee, University of Trento graduate student Roberta Lentini, to work with the Bentley Group in College Park. The two students' research is complimentary.

"Roberta is working on an artificial cell that can respond to a quorum sensing signal [molecule], autoinducer-2, and I am building one that can synthesize and deliver autoinducer-2," Terrell explains.

"This project is groundbreaking because it changes the way we can program living cells," says Bentley. "Synthetic biology is largely stuck on the single viewpoint that in order to modify cellular behavior, the genetic content of the cell must be changed. Our new approach transiently and safely directs the function of natural cells using messages, in the form of signalling molecules, manufactured and sent by artificial ones."

The technology, he adds, has far-reaching implications. "Cell-like systems capable of this sort of communication could be built to block bacterial transitions to virulent states, which could lead to the treatment of infections without antibiotics, and to guide stem cell differentiation, which could lead to improved tissue regeneration for people with serious injuries."

The exchange is part of an ongoing collaboration between the Bentley and Mansy Groups. The project, "Control of Living Cells Through Communication with Artificial Cells," is one of three funded by the Autonomous Province of Trento as part of a formal partnership cemented between the province and the University of Maryland in 2011. Management and implementation of the program will be shared among representatives of both organizations; in College Park these efforts will be directed by Professor Reza Ghodssi, director of the A. James Clark School of Engineering's Institute for Systems Research (ISR).

Related Articles:
Museum Conservation Research Wins Top Prizes in International 3-Minute Thesis Competition
International research partnership leads to major publication on controlling living cells with artificial cells
New Advance in Biochip Research
Ghodssi, Rubloff part of $2 million NSF grant
"Side Effects May Not Include?"
$1 Million For Nano-Bio Initiative

April 15, 2013

«Previous Story  



Current Headlines

Postdoc Candidate Sought at Naval Research Laboratory

Engineering at Maryland magazine introduces new leader, new look

You Can Make It at Maryland

UMD Scientists Convert Methane without Greenhouse Gas Emissions

Wood That Can Cut Like Steel, Be Molded Like Plastic or Build Batteries?

UMD-Led Team Wins NSF Award for Rapid Materials Design

Expanded Wood Fiber for High-Performance Solid-State Paper Batteries

USMSM Debuts SMART Innovation Center

Incentive Awards Program, Engineering Lab Building Named for Mote

Improving Disaster Communication for Marginalized Communities


Colleges A. James Clark School of Engineering
The College of Computer, Mathematical, and Natural Sciences

Communicate Join Email List
Contact Us
Follow us on TwitterTwitter logo

Links Privacy Policy

Copyright The University of Maryland University of Maryland